FACTS ABOUT KETAMINE QT PROLONGATION REVEALED

Metabolism Ketamine is metabolized through N-dealkylation into the Lively metabolite norketamine mostly by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation on the cyclohexone ring to variety hydroxynorketamine compounds via CYP-dependent pathways, which are conjugated with glucuronic acid and subse